Pot Pill Doesn’t Lessen Dementia Symptoms

http://www.medpagetoday.com/Neurology/Dementia

In a randomized controlled trial, patients who were taking either placebo or oral tetrahydrocannabinol (THC, Namisol) had similar reductions in neuropsychiatric symptoms, reported Geke van den Elsen, MD, of Radboud University Medical Center in Nijmegen [Netherlands], and colleagues.  However, they pointed out that the 4.5-mg daily dose was well-tolerated, so a dosage increase may boost efficacy, they wrote online in Neurology…

Since firm evidence of the efficacy and safety of THC and other cannabinoids in dementia patients are lacking, they conducted a study of 50 patients who were randomized to either placebo or to 1.5 mg of oral THC three times a day for 3 weeks…

http://www.echo-pharma.com/en/products-and-pipeline/namisol/

Namisol® is the world’s first oral tablet that contains pure, natural Δ9-THC (dronabinol) in fixed dosages with high, predictable bioavailability and a long, stable shelf life at room temperature.

Namisol® is also the first major implementation of our innovative lipophilic compound Drug Delivery Technology Alitra™, and our main focus in the pharmaceutical development program. Namisol® is set to be registered for a number of indications, including Multiple Sclerosis (MS), behavioral disturbances in patients with Alzheimer’s Disease, and Chronic Pain.

The efficacy of Namisol® in patients with Multiple Sclerosis, Alzheimer’s and Chronic Pain is being researched. Additional indications are being examined. After successful completion of pre-clinical and clinical Phase I studies, Namisol® is now in Phase II of clinical development…

I’m a proponent of THC, but without all the other CBDs in cannabis, you’re getting a different and incomplete effect.  And 1.5mg is a pretty low dose.  It would be nice to see a study of patients who are at risk for dementia or in the beginning stages of this condition, as I think that will be where the real benefits lie.

As for treating chronic pain patients, the same issues would apply, only more so.  As a chronic pain patient, I would not be interested in a THC-only pill.

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