FDA keeps black box on Pfizer’s Chantix, adds new warning about alcohol


Now, the agency has itself spoken. And it’s choosing not only to keep the black box, which highlights warnings about suicide and suicidal thoughts, but also to add new cautionary advice about Chantix’s interactions with alcohol. Some Chantix patients have reported unusual or aggressive behavior while drinking, the agency says. A few have experienced seizures…

Patients should cut down on alcohol when they start taking the drug, to see how they might react to the combination, the FDA says, because patients have reported decreased tolerance to alcohol…


It’s the only partial agonist approved for opioid addiction, but it’s comparable to varenicline (Chantix), a partial agonist for smoking cessation…


11/15/2013, Hypotension and bradycardia following varenicline overdose

Conclusion: Varenicline is a new drug and very little is known about its effects in overdose. This case suggests that toxicity may be seen at a dose which is relatively small compared to previously reported cases.


Marketed as Wellbutrin and Zyban, among other trade names, it is one of the most frequently prescribed antidepressants in the United States, although in many English-speaking countries, including the United Kingdom, Australia and New Zealand, this is an off-label use…

In any case, bupropion, via non-conventional routes of administration (e.g., injection, insufflation), is reported to be abused in Canada, and in recent years in United States prisons...


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