Two dead in apparent murder-suicide at NYC Home Depot: NYPD

https://news.yahoo.com/two-dead-apparent-murder-suicide-nyc-home-depot-221012428–finance.html

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(2006) Paracetamol: new vistas of an old drug.

http://www.ncbi.nlm.nih.gov/pubmed/17227290

Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever. It occupies a unique position among analgesic drugs. Unlike NSAIDs it is almost unanimously considered to have no antiinflammatory activity and does not produce gastrointestinal damage or untoward cardiorenal effects. Unlike opiates it is almost ineffective in intense pain and has no depressant effect on respiration. Although paracetamol has been used clinically for more than a century, its mode of action has been a mystery until about one year ago, when two independent groups (Zygmunt and colleagues and Bertolini and colleagues) produced experimental data unequivocally demonstrating that the analgesic effect of paracetamol is due to the indirect activation of cannabinoid CB(1) receptors…

These findings finally explain the mechanism of action of paracetamol and the peculiarity of its effects, including the behavioral ones. Curiously, just when the first CB(1) agonists are being introduced for pain treatment, it comes out that an indirect cannabino-mimetic had been extensively used (and sometimes overused) for more than a century.

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2814%2960805-9/abstract

7/23/2014, Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial

Background:  Regular paracetamol is the recommended first-line analgesic for acute low-back pain; however, no high-quality evidence supports this recommendation. We aimed to assess the efficacy of paracetamol taken regularly or as-needed to improve time to recovery from pain, compared with placebo, in patients with low-back pain…

Interpretation:  Our findings suggest that regular or as-needed dosing with paracetamol does not affect recovery time compared with placebo in low-back pain, and question the universal endorsement of paracetamol in this patient group.

Funding:  National Health and Medical Research Council of Australia and GlaxoSmithKline Australia

http://ard.bmj.com/content/70/9/1521.full

(2011) Paracetamol, ibuprofen, or a combination of both drugs against knee pain: an excellent new randomised clinical trial answers old questions and suggests new therapeutic recommendations

Concerning pain relief, the data clearly show that (1) paracetamol 1000 mg three times a day does not provide satisfactory pain relief in the majority of patients; (2) neither the high- nor the low-dose combination of ibuprofen with paracetamol is superior to ibuprofen alone; and (3) ibuprofen alone or combined with paracetamol is superior to paracetamol alone…

Vanderbilt Rape Trial Evidence: Several People Failed To Intervene For Unconscious Woman

http://www.huffingtonpost.com/2015/01/24/vanderbilt-rape-evidence_n_6538708.html

The graphic evidence and testimony presented in court is all the more shocking because it shows that several others were at least partly aware that an unconscious woman was being taken advantage of or had enough evidence to show that something had happened to her, and did nothing to help her or report it…

They were shocked to see players carrying an unconscious woman into an elevator and down a hallway, taking compromising pictures of her and then dragging her into the room…

The woman – a neuroscience student who had been dating Vandenburg before the alleged rape and returned to Nashville to testify – cried softly and the jurors stared wide-eyed as a detective narrated the videos Vandenburg shared and described the pictures taken on their cellphones.

She testified that she woke up in Vandenburg’s dorm room bed the next morning with her clothes on, and still has no memory of anything that happened after Vandenburg passed her drinks the night before, some of which were purchased for the players by a team booster…