(2006) Paracetamol: new vistas of an old drug.


Paracetamol (acetaminophen) is one of the most popular and widely used drugs for the treatment of pain and fever. It occupies a unique position among analgesic drugs. Unlike NSAIDs it is almost unanimously considered to have no antiinflammatory activity and does not produce gastrointestinal damage or untoward cardiorenal effects. Unlike opiates it is almost ineffective in intense pain and has no depressant effect on respiration. Although paracetamol has been used clinically for more than a century, its mode of action has been a mystery until about one year ago, when two independent groups (Zygmunt and colleagues and Bertolini and colleagues) produced experimental data unequivocally demonstrating that the analgesic effect of paracetamol is due to the indirect activation of cannabinoid CB(1) receptors…

These findings finally explain the mechanism of action of paracetamol and the peculiarity of its effects, including the behavioral ones. Curiously, just when the first CB(1) agonists are being introduced for pain treatment, it comes out that an indirect cannabino-mimetic had been extensively used (and sometimes overused) for more than a century.


7/23/2014, Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial

Background:  Regular paracetamol is the recommended first-line analgesic for acute low-back pain; however, no high-quality evidence supports this recommendation. We aimed to assess the efficacy of paracetamol taken regularly or as-needed to improve time to recovery from pain, compared with placebo, in patients with low-back pain…

Interpretation:  Our findings suggest that regular or as-needed dosing with paracetamol does not affect recovery time compared with placebo in low-back pain, and question the universal endorsement of paracetamol in this patient group.

Funding:  National Health and Medical Research Council of Australia and GlaxoSmithKline Australia


(2011) Paracetamol, ibuprofen, or a combination of both drugs against knee pain: an excellent new randomised clinical trial answers old questions and suggests new therapeutic recommendations

Concerning pain relief, the data clearly show that (1) paracetamol 1000 mg three times a day does not provide satisfactory pain relief in the majority of patients; (2) neither the high- nor the low-dose combination of ibuprofen with paracetamol is superior to ibuprofen alone; and (3) ibuprofen alone or combined with paracetamol is superior to paracetamol alone…

Vanderbilt Rape Trial Evidence: Several People Failed To Intervene For Unconscious Woman


The graphic evidence and testimony presented in court is all the more shocking because it shows that several others were at least partly aware that an unconscious woman was being taken advantage of or had enough evidence to show that something had happened to her, and did nothing to help her or report it…

They were shocked to see players carrying an unconscious woman into an elevator and down a hallway, taking compromising pictures of her and then dragging her into the room…

The woman – a neuroscience student who had been dating Vandenburg before the alleged rape and returned to Nashville to testify – cried softly and the jurors stared wide-eyed as a detective narrated the videos Vandenburg shared and described the pictures taken on their cellphones.

She testified that she woke up in Vandenburg’s dorm room bed the next morning with her clothes on, and still has no memory of anything that happened after Vandenburg passed her drinks the night before, some of which were purchased for the players by a team booster…

‘American Sniper’ Triggers Flood Of Anti-Muslim Venom, Civil Rights Group Warns


Bart Rowe · Top Commenter · Linn–Benton Community College

1. Iraq had nothing to do with 9/11 and it’s completely disgusting that the movie implies that it did.

2. If you’re so gung-ho about wanting to “kill them a-rabs”, feel free to walk down to your local Army recruitment station and join up.

3. We invaded Iraq on false pretenses and killed thousands of civilians whilst doing so. We were the bad guys. We are the reason ISIS now exists. Please understand basic facts.




Re: The shortage has ended!
I appreciate the update, and I’m glad the program is working for you. Sounds like you had a good harvest, too. I’m happy for you, lavieboo, I really am.

And I’m trying not to be bitter or angry about not having enough money to renew (even though I moved from Texas to join this program), or about having to manage constant pain with aspirin and sugar. About days of no sleep and negative thoughts I’d rather not have. About how hard it was to try and make the program work for me, when all that time and effort just left me penniless, with nowhere to legally turn to treat a 25-year intractable pain condition…

I’m so glad all of the 11,000 medical cannabis patients in New Mexico are happy with the program. Really, I am.

Painfully Alone and Desperate in Albuquerque,
Johnna Stahl

Australia rallies behind dad facing prison over cannabis oil for sick child


He was charged with supplying a dangerous drug to a minor and faces up to 25 years in prison if convicted.

An online petition calling on the Queensland state Premier Campbell Newman to intervene on the father’s behalf had more than 155,000 supporters on Thursday…

Voices of pain patients (Maine)


Kathy Shiplett
January 21 at 1:04pm
I, too, suffer from chronic pain and am being weaned off morphine. I have been using it successfully and responsibly for over 15 years. No health problems other than the intense pain with neuropathy of failed back surgery, and frequent migraines as well. I am 100% disabled, according to the social security administration, and we know how stringent their rules are. I am in so much pain now I am losing all hope, the exact way I felt before I began long-acting morphine. My doctor at the pain clinic said “I will not go up on your meds even if this doesn’t work.” (He said current medical thinking is that people experience the same amount of pain whether they take narcotics or not (!!!). This is not life. It is death. I am in Maine, so you see it is a nationwide problem.

FDA Zeros In on Abuse-Deterrent Opioids


[I tried to post this comment at the National Pain Report website on its article for CR845 — twice. But my comment was censored and not posted. Since that’s the first time I’ve been censored on the National Pain Report website, I have to conclude that my comment touched a nerve. After all, who’s afraid of the truth? I’ve also concluded that the website is not really for pain patients — it appears to be a front for the investors involved with CR845. Therefore, I’ve unsubscribed to that website and will no longer be posting there. And I just thought pain patients should be aware of the truth behind the websites they are supporting.]

November 11, 2014 at 8:39 pm

At first I thought CR845 was another Celebrex. Then, with a little more digging, I figured out we’re talking about another Suboxone.

From Wikipedia page for “κ-opioid receptor”: “However, KOR agonists also produce side effects such as dysphoria and hallucinations, which limits their clinical usefulness.”

I’m confused. Have these drugs been successful for anything other than the treatment of addiction (if that)? Because most of what I’ve read about this drug’s effectiveness to treat pain is not good (I’m talking about from actual patients, not studies). In fact, I am very interested in hearing from any patients who’ve taken these new biopharmaceutical concoctions.

Additionally, I’ve read that these kinds of drugs are also part of the opioid abuse “epidemic.” I think the worst thing I’ve read about Naloxone was at Wikipedia: “Studies show that to give this to a person in severe pain would be unethical and inhumane.” (Yikes.)

“We really need to find something that doesn’t have rewarding properties that doesn’t lead to addiction,” said Lynn Webster, MD, past president of the American Academy of Pain Medicine, who was the lead investigator in initial studies of the drug.

For 95% of chronic pain patients, we already have drugs that don’t lead to addiction. And it is within that “reward” effect where most pain relief is found. Regardless, most chronic pain patients don’t get “high,” so that’s not the reason that a very small percentage of us become addicted.

What we’ve got here is a treatment for addiction, not pain. It just so happens that addiction causes pain — but most chronic pain patients are not suffering from that kind of pain.

As for the percentage of the population who suffer from addiction at any given time, they will use whatever drugs are available and affordable — regardless of the sorcery of the biopharmaceutical industry. What, you think doctors and scientists know more about drugs than addicts?

Ya’ll should be studying and researching endocannabinoids — that’s the future. If you’re against the psychoactive effect, then just look at CBDs other than THC — I think there are over 70 of them (so far).

%d bloggers like this: