The mild opioid tramadol was associated with an increased risk of hospitalization for hypoglycemia, researchers reported.
In a case-control study, the use of tramadol was associated with a 52% higher risk of hospitalization for hypoglycemia compared with codeine…
Tramadol is seen as a lower-risk alternative to other opioids and its prescriptions have increased in recent years. In August, the opioid became a schedule IV controlled substance.
It’s also unclear why hypoglycemia is less common in patients taking other mu-opioid agonists such as morphine, oxycodone, and hydrocodone, they note.